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In vitro ADME Service
- Liver microsomal stability(LC/MSMS)
- Aqueous solubility (Nephelometry)
- Plasma protein binding (LC/MSMS)
- Plasma stability (LC/MSMS)
- CYP % Inhibition & IC50 (Microplate reader)
- GI, BBB-PAMPA permeability assay(LC/MSMS)
- hERG fluorescence polarization assay
- Formulation analysis (Stability, homogeneity)
- Formulation test (Stability, homogeneity)
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In vivo ADME Service
- Rodent PK study (Includes Cassette PK test)
- Formulation test using Beagle Dog
- Dose dependent study
- Bioavailability
- Gender difference
- Food effects
- Tissue distribution (contains tumor)
- Metabolite analysis
- Urine, bile excretion analysis
- BBB assessment(brain to plasma partition coefficient; Kp value)
- Non-rodent PK study: Preliminary investigation in bioequivalence test using Beagle dog.
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Chemical structure analysis(NMR)
- 1H & 13C
- Evaluation of MOD, % (modification of degree) at Hyaluronic Acid
- Directyl use
- Commissioned service
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Research equipment support Service
- Nephelometry
- FT-IR
- Microplate reader (UV, Fluorescence, Polarization)
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SPR Service
- Kinetic analysis
- Binding assay
- Affinity analysis
- Biacore T200 [Cytiva] / SR7500DC [Reichert]
CRO
Pharmaceutical Analysis Services
약물분석 서비스는
전문인력의 신속 정확한 분석법 개발과
최고 사양의 LC-MS/MS를 활용한 In vitro & In vivo ADME 서비스,
Plasma, urine, tissue, tumor 등 다양한 생체시료 분석 서비스를 제공합니다.